You can read our earlier reviews of Eternal Sabbath vol. 1 here, vol. 2 here and vols. 3-4 here.
Through these volumes, Shuro and Mine try to influence Isaac by way of his friend Yuri. Although they make careful moves, things take a turn for the worse. Isaac does show some signs of human emotion, but he doesn't know how to act on them correctly. In the process of erasing his "mistakes" he sets off another encounter with Shuro. When the scene escalates, Isaac actually seems off balance due to the emotional fallout from Yuri, and the plot begins to shift in a new direction.
Tough subjects are tackled in these three volumes -- child abuse, the stresses of parenting -- and this series will be staying on my short list!
ES vol. 1, vol. 2, vol. 3 vol. 4, vol. 5, vol. 6 and vol. 7 are all available from Right Stuf, Intl., an online retailer specializing in anime and manga.